Pieters M H, Dumoulin J C, Engelhart C M, Bras M, Evers J L, Geraedts J P
Academische Ziekenhuis Maastricht, The Netherlands.
Fertil Steril. 1991 Aug;56(2):306-10.
To study immaturity and aneuploidy in human oocytes after two different stimulation protocols.
Retrospective.
Outpatient IVF clinic/laboratory.
One hundred forty-three patients of whom 65 were stimulated with clomiphene citrate (CC)/human menopausal gonadotropin (hMG) and 78 were stimulated with gonadotropin-releasing hormone agonist (GnRH-a)/hMG. Only patients with at least one oocyte unfertilized were included in this study.
Stimulation with GnRH-a/hMG, as compared with CC/hMG stimulation, resulted in larger numbers of oocytes (P less than 0.00001), a higher fertilization rate (P less than 0.02), and oocyte retrieval at a later average cycle day (P less than 0.000005). Cytogenetic findings of immaturity were observed in 33.9% of unfertilized oocytes after CC/hMG stimulation, compared with only 17.8% after GnRH-a/hMG stimulation (P less than 0.0005). Aneuploidy findings were the same for both groups.
In GnRH-a/hMG stimulation, oocytes approach the normal day of ovulation more closely. This may allow for better oocyte maturation and higher fertilization and pregnancy rates.
研究两种不同刺激方案后人卵母细胞的未成熟和非整倍体情况。
回顾性研究。
门诊体外受精诊所/实验室。
143例患者，其中65例用枸橼酸氯米芬（CC）/人绝经期促性腺激素（hMG）刺激，78例用促性腺激素释放激素激动剂（GnRH-a）/hMG刺激。本研究仅纳入至少有一个未受精卵母细胞的患者。
与CC/hMG刺激相比，GnRH-a/hMG刺激产生的卵母细胞数量更多（P<0.00001），受精率更高（P<0.02），且平均取卵时间更晚（P<0.000005）。CC/hMG刺激后，33.9%的未受精卵母细胞出现未成熟的细胞遗传学结果，而GnRH-a/hMG刺激后仅为17.8%（P<0.0005）。两组的非整倍体结果相同。
在GnRH-a/hMG刺激中，卵母细胞更接近正常排卵日。这可能使卵母细胞成熟更好，受精率和妊娠率更高。
