Rosenbusch B, Sterzik K, Sasse V, Djalali M
Abteilung Frauenheilkunde und Geburtshilfe, Universität Ulm.
Zentralbl Gynakol. 1993;115(5):225-7.
A cytogenetic analysis could be performed on 343 out of 566 oocytes which remained unfertilized or uncleaved during our in vitro fertilization (IVF) programme. The results were analyzed in relation to the kind of ovarian stimulation by classification of the patients into two groups: treatment with human menopausal gonadotropin (hMG) or treatment with clomiphene citrate (CC). There was no significant difference for the total rates of abnormal oocytes (hMG: 28.6%, CC: 32.2%), the rates of aneuploidy (hMG: 14.4%, CC: 16.9%), and the rates of hyperhaploidy (hMG: 3.9%, CC: 8.5%). These results suggest that the kind of medication for induction of multiple follicular growth does not influence the rate of cytogenetic anomalies in human oocytes.
在我们的体外受精（IVF）程序中，对566个未受精或未分裂的卵母细胞中的343个进行了细胞遗传学分析。根据卵巢刺激的类型将患者分为两组：用人绝经期促性腺激素（hMG）治疗或用枸橼酸氯米芬（CC）治疗，对结果进行了分析。异常卵母细胞的总发生率（hMG：28.6%，CC：32.2%）、非整倍体发生率（hMG：14.4%，CC：16.9%）和超单倍体发生率（hMG：3.9%，CC：8.5%）没有显著差异。这些结果表明，诱导多个卵泡生长的药物种类不会影响人类卵母细胞的细胞遗传学异常发生率。
