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运动员关节软骨损伤的新兴治疗选择。

Emerging options for treatment of articular cartilage injury in the athlete.

作者信息

Mithoefer Kai, McAdams Timothy R, Scopp Jason M, Mandelbaum Bert R

机构信息

Harvard Vanguard Orthopedics and Sports Medicine, Harvard Medical School, Boston, MA, USA.

出版信息

Clin Sports Med. 2009 Jan;28(1):25-40. doi: 10.1016/j.csm.2008.09.001.

Abstract

Articular cartilage injury is observed with increasing frequency in both elite and amateur athletes and results from the significant joint stress associated particularly with high-impact sports. The lack of spontaneous healing of these joint surface defects leads to progressive joint pain and mechanical symptoms with resulting functional impairment and limitation of athletic participation. Left untreated, articular cartilage defects can lead to chronic joint degeneration and athletic disability. Articular cartilage repair in athletes requires effective and durable joint surface restoration that can withstand the significant joint stresses generated during athletic activity. Several techniques for articular cartilage repair have been developed recently, which can successfully restore articular cartilage surfaces and allow for return to high-impact athletics after articular cartilage injury. Besides these existing techniques, new promising scientific concepts and techniques are emerging that incorporate modern tissue engineering technologies and promise further improvement for the treatment of these challenging injuries in the demanding athletic population.

摘要

在精英运动员和业余运动员中,关节软骨损伤的发生率都在不断增加,这是由特别是与高冲击性运动相关的巨大关节压力导致的。这些关节表面缺损缺乏自然愈合能力,会导致渐进性关节疼痛和机械性症状,进而造成功能障碍和运动参与受限。若不进行治疗,关节软骨缺损会导致慢性关节退变和运动能力丧失。运动员的关节软骨修复需要有效且持久的关节表面修复,以承受运动活动中产生的巨大关节压力。最近已经开发出几种关节软骨修复技术,这些技术可以成功修复关节软骨表面,并使运动员在关节软骨损伤后能够恢复到高冲击性运动中。除了这些现有技术外,新的有前景的科学概念和技术也在不断涌现,它们融合了现代组织工程技术,有望在要求苛刻的运动员群体中进一步改善这些具有挑战性损伤的治疗效果。

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