Glisson Christopher C, Galetta Steven L
Department of Neurology and Ophthalmology, Michigan State University College of Human Medicine, 260 Jefferson SE, Suite 217, Grand Rapids, MI 49503, USA.
Neuroimaging Clin N Am. 2009 Feb;19(1):71-9. doi: 10.1016/j.nic.2008.09.003.
Conventional MR imaging is, at present, the most important paraclinical modality for assessing the risk of MS in patients with acute demyelinating ON and for monitoring the progression of disease. However, there are limitations of conventional MR in imaging the optic nerve. Newer strategies, MT MR imaging, DT MR imaging, and OCT, show significant promise. Future investigations, including the use of nonconventional MR imaging techniques coupled with OCT and functional measures of anterior visual pathway function, will further assist in the early detection of clinical impairment. Serial analysis will allow for monitoring of disease progression, predict accumulation of disability, and ascertain the effects of candidate neuroprotective therapies.
目前，传统磁共振成像（MR）是评估急性脱髓鞘性视神经炎（ON）患者发生多发性硬化（MS）风险以及监测疾病进展的最重要的临床辅助检查手段。然而，传统MR对视神经成像存在局限性。更新的技术，如磁共振磁敏感加权成像（MT MR）、磁共振扩散张量成像（DT MR）和光学相干断层扫描（OCT），显示出巨大的前景。未来的研究，包括将非传统MR成像技术与OCT以及前视觉通路功能的功能测量相结合，将进一步有助于早期发现临床损伤。系列分析将有助于监测疾病进展、预测残疾累积情况，并确定候选神经保护疗法的效果。
