新型两性离子三嗪鎓盐1-甲基-3-苯基-1,2,4-三嗪鎓-5-醇盐对小鼠免疫反应及实验性布鲁氏菌病的影响

Effect of the novel triazinium zwitterion 1-methyl-3-phenyl-1,2,4-triazinium-5-olate on immunological responses and experimental brucellosis in mice.

作者信息

Zeng T S, Halliday W J, Jacobsen N W, Seow W K, Thong Y H

机构信息

Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.

出版信息

Int J Immunopharmacol. 1991;13(2-3):135-40. doi: 10.1016/0192-0561(91)90090-t.

DOI:10.1016/0192-0561(91)90090-t

PMID:1906435

Abstract

The immunopharmacology of a novel triazinium zwitterion, designated JR-6, was studied in mice. Experiments show dose-response inhibition of antibody and delayed-type hypersensitivity (DTH) responses to sheep red blood cell antigens. Suppression of DTH was confirmed using trinitrochlorobenzene as a contact-sensitizing antigen. Using a model of experimental brucellosis in mice, it was found that JR-6 caused suppression of specific antibody and DTH reaction, as well as spleen weight, but a statistically significant increase in viable counts of Brucella abortus was not observed. Extensive short-term toxicology studies showed reduction in lymphocyte and neutrophil counts, and slow weight gain of treated mice. However, organ histology, liver function tests and biochemical profiles were normal.

摘要

在小鼠中研究了一种名为JR-6的新型三嗪鎓两性离子的免疫药理学。实验表明，它对绵羊红细胞抗原的抗体和迟发型超敏反应（DTH）有剂量依赖性抑制作用。使用三硝基氯苯作为接触致敏抗原来证实DTH的抑制作用。在小鼠实验性布鲁氏菌病模型中发现，JR-6可抑制特异性抗体和DTH反应以及脾脏重量，但未观察到流产布鲁氏菌活菌计数有统计学意义的增加。广泛的短期毒理学研究表明，治疗小鼠的淋巴细胞和中性粒细胞计数减少，体重增加缓慢。然而，器官组织学、肝功能测试和生化指标均正常。