双苄基异喹啉生物碱粉防己碱和小檗胺的比较免疫药理学与毒理学
Comparative immunopharmacology and toxicology of the bisbenzylisoquinoline alkaloids tetrandrine and berbamine.
作者信息
Wong C W, Seow W K, Zeng T S, Halliday W J, Thong Y H
机构信息
Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
出版信息
Int J Immunopharmacol. 1991;13(5):579-85. doi: 10.1016/0192-0561(91)90079-m.
Comparison of the bisbenzylisoquinolines tetrandrine and berbamine shows that both drugs are equipotent in terms of enhancement of antibody responses and suppression of delayed-type hypersensitivity (DTH) responses to sheep red blood cell antigens. Both compounds are also equally active when given to mice during the induction and expression phases of DTH. Using a model of experimental brucellosis in mice, it was found that both compounds did not affect antibody responses, while they caused equipotent suppression of DTH. By contrast, berbamine but not tetrandrine caused significant suppression of spleen weight. Also, berbamine caused a significantly greater enhancement of spleen colony counts of Brucella abortus than tetrandrine. Short-term toxicology studies showed no toxic effects at bioactive doses.
双苄基异喹啉类药物粉防己碱和小檗胺的比较表明，在增强抗体反应以及抑制对绵羊红细胞抗原的迟发型超敏反应（DTH）方面，这两种药物的效力相当。在DTH的诱导期和表达期给予小鼠时，这两种化合物的活性也相同。利用小鼠实验性布鲁氏菌病模型发现，这两种化合物均不影响抗体反应，但它们对DTH的抑制作用相当。相比之下，小檗胺而非粉防己碱可导致脾脏重量显著减轻。此外，小檗胺比粉防己碱能更显著地提高流产布鲁氏菌的脾脏集落计数。短期毒理学研究表明，在生物活性剂量下无毒性作用。
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