Allen Naomi E, Appleby Paul N, Roddam Andrew W, Tjønneland Anne, Johnsen Nina Føns, Overvad Kim, Boeing Heiner, Weikert Steffen, Kaaks Rudolf, Linseisen Jakob, Trichopoulou Antonia, Misirli Gesthimani, Trichopoulos Dimitrios, Sacerdote Carlotta, Grioni Sara, Palli Domenico, Tumino Rosario, Bueno-de-Mesquita H Bas, Kiemeney Lambertus A, Barricarte Aurelio, Larrañaga Nerea, Sánchez Maria-José, Agudo Antonio, Tormo María-José, Rodriguez Laudina, Stattin Pär, Hallmans Göran, Bingham Sheila, Khaw Kay-Tee, Slimani Nadia, Rinaldi Sabina, Boffetta Paolo, Riboli Elio, Key Timothy J
Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Am J Clin Nutr. 2008 Dec;88(6):1567-75. doi: 10.3945/ajcn.2008.26205.
Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer.
The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors.
A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls.
Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration.
Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men.
一些证据表明，低硒摄入量可能与前列腺癌风险增加有关。
本研究的目的是调查血浆硒浓度与随后前列腺癌风险之间的关联，并按疾病分期、分级及其他因素来检验这种关联。
在欧洲癌症与营养前瞻性调查（EPIC）中对男性进行了一项巢式病例对照研究。在959例前列腺癌患者及1059例匹配对照中评估了血浆硒浓度与前列腺癌风险之间的关联。
总体而言，血浆硒浓度与前列腺癌风险无关；与最低五分位数相比，硒浓度最高五分位数男性的多变量相对风险为0.96（95%可信区间：0.70，1.31；趋势P值 = 0.25）。按疾病分期或分级分析时，血浆硒与风险之间的关联无显著差异。同样地，硒与风险之间的关联在吸烟状况、血浆α-或γ-生育酚浓度方面也无差异。
在这一大型欧洲男性队列中，血浆硒浓度与前列腺癌风险无关。
