Kalmyrzaev Bolot, Pharoah Paul D P, Easton Douglas F, Ponder Bruce A J, Dunning Alison M
University of Cambridge Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN United Kingdom.
Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3618-20. doi: 10.1158/1055-9965.EPI-08-0216.
A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint analysis of two small case-control studies. We have examined the association of these single nucleotide polymorphisms, together with others tagging the HMMR gene, in a larger, European case-control study and find no association of any of them with risk of breast cancer: rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9], rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].
最近的一项研究采用网络建模策略来生成一组由潜在功能关联连接的基因。透明质酸介导的运动受体（HMMR）基因被确定为与BRCA1存在功能关联，因此是一个候选乳腺癌基因。在两项小型病例对照研究的联合分析中，单核苷酸多态性（SNP）rs10515860、rs299290和rs7712023被报告与乳腺癌显著相关。我们在一项更大规模的欧洲病例对照研究中检测了这些单核苷酸多态性以及其他标记HMMR基因的多态性与乳腺癌风险的关联，发现它们均与乳腺癌风险无关：rs10515860 [比值比（OR；AA/GG），0.85；95%置信区间（CI），0.65 - 1.12；P（趋势） = 0.9]，rs299290 [OR（CC/TT），1.00；95% CI，0.87 - 1.15；P（趋势） = 0.7]，rs3756648（rs7712023）[OR（TT/CC），0.93；95% CI，0.84 - 1.02；P（趋势） = 0.1]，rs299284 [OR（TT/CC），1.01；95% CI，0.76 - 1.35；P（趋势） = 0.5]，以及rs13183712 [OR（TT/GG），1.04；95% CI，0.88 - 1.23；P（趋势） = 0.6]。
