Jones Theresa A, Allred Rachel P, Adkins Deanna L, Hsu J Edward, O'Bryant Amber, Maldonado Mónica A
Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
Stroke. 2009 Mar;40(3 Suppl):S136-8. doi: 10.1161/STROKEAHA.108.533653. Epub 2008 Dec 8.
Behavioral experience can drive brain plasticity, but we lack sufficient knowledge to optimize its therapeutic use after stroke.
We outline recent findings from rodent models of cortical stroke of how experiences interact with postinjury events to influence synaptic connectivity and functional outcome. We focus on upper extremity function.
After unilateral cortical infarcts, behavioral experiences shape neuronal structure and activity in both hemispheres. Experiences that matter include interventions such as skill training and constraint-like therapy as well as unguided behaviors such as learned nonuse and behavioral compensation. Lateralized behaviors have bihemispheric influences. Ischemic injury can alter the sensitivity of remaining neocortical neurons to behavioral change and this can have positive and negative functional effects.
Because experience is ongoing in stroke survivors, a better understanding of its interaction with brain reorganization is needed so that it can be manipulated to improve function and prevent its worsening.
行为经验可驱动大脑可塑性，但我们缺乏足够的知识来优化其在中风后的治疗应用。
我们概述了近期来自皮质中风啮齿动物模型的研究结果，内容涉及经验如何与损伤后事件相互作用以影响突触连接和功能结局。我们重点关注上肢功能。
单侧皮质梗死之后，行为经验塑造了双侧半球的神经元结构和活动。重要的经验包括技能训练和类似限制疗法等干预措施，以及习得性废用和行为代偿等无指导行为。偏侧化行为具有双侧半球影响。缺血性损伤可改变剩余新皮质神经元对行为变化的敏感性，这可能产生积极和消极的功能影响。
由于中风幸存者的经验是持续存在的，因此需要更好地理解其与大脑重组的相互作用，以便对其进行调控以改善功能并防止其恶化。
