Yaseen Mohammad A, Yu Jie, Wong Michael S, Anvari Bahman
Department of Bioengineering, Rice University, MS-142 6100 Main St, Houston, TX 77005, USA.
Opt Express. 2008 Dec 8;16(25):20577-87. doi: 10.1364/oe.16.020577.
Indocyanine green (ICG) is a fluorescent probe used in clinical imaging. However, its utility remains limited by optical instability, rapid circulation kinetics, and exclusive uptake by the liver. Using mesocapsule (MC) constructs to encapsulate ICG, we have developed a technology to stabilize ICG's optical properties and alter its biodistribution. We present in vivo fluorescence images of mammalian organs to demonstrate the potential application of our ICG encapsulation technology for optical imaging of specific tissues.
吲哚菁绿（ICG）是一种用于临床成像的荧光探针。然而，其效用仍然受到光学不稳定性、快速循环动力学以及肝脏的排他性摄取的限制。通过使用中囊泡（MC）构建体来包裹ICG，我们开发了一种技术来稳定ICG的光学性质并改变其生物分布。我们展示了哺乳动物器官的体内荧光图像，以证明我们的ICG包裹技术在特定组织光学成像方面的潜在应用。
