病毒模拟纳米结构作为近红外光声成像的对比剂。
Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging.
机构信息
Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA.
出版信息
Nanoscale. 2013 Mar 7;5(5):1772-6. doi: 10.1039/c3nr34124k. Epub 2013 Jan 21.
Abstract
We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG. Our preliminary results suggest that the constructs do not elicit an acute immunogenic response in healthy mice.
摘要
我们首次证明了使用由植物病毒蛋白壳组成的造影剂进行光声成象的原理，该造影剂包裹了吲哚菁绿（ICG），这是唯一获得美国食品和药物管理局批准的近红外发色团。这些纳米结构在组织体模中的光声信号比血液高，并且与未包裹的 ICG 相比具有更好的光稳定性。我们的初步结果表明，这些结构在健康小鼠中不会引起急性免疫反应。
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