百草枯对大鼠肺脯氨酰羟化酶的影响。
Effect of paraquat on rat lung prolyl hydroxylase.
作者信息
Hollinger M A, Chvapil M
出版信息
Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):159-62.
PMID:190657
Abstract
Acute administration of Paraquat (25 mg/kg, I.P.) was found to significantly increase prolyl hydroxylase in rat lung 7 days following treatment. There was no change in total collagen at this time point. At 21 days following drug treatment, total collagen was significantly elevated while prolyl hydroxylase activity had returned to control level.
摘要
研究发现，腹腔注射百草枯（25毫克/千克）后7天，大鼠肺中的脯氨酰羟化酶显著增加。此时总胶原蛋白没有变化。药物治疗21天后，总胶原蛋白显著升高，而脯氨酰羟化酶活性已恢复到对照水平。
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