实验性百草枯中毒时的胶原蛋白脯氨酰羟化酶水平
Collagen prolyl hydroxylase levels in experimental paraquat poisoning.
作者信息
Thompson W D, Patrick R S
出版信息
Br J Exp Pathol. 1978 Jun;59(3):288-91.
Abstract
Collagen prolyl hydroxylase activity was measured in lung, liver, kidney and serum in rats killed on 7 successive days following a single toxic dose of paraquat. The enzyme activity in liver initially fell, then returned to normal, and no change was found in kidney. In contrast a 5-fold rise was observed in lung enzyme level, reaching of maximum on the 5th day. A parallel rise in serum activity was also found. The onset of these enzyme elevations corresponds to the early histological appearance of cellular proliferation in lung alveoli.
摘要
在给予大鼠单次中毒剂量百草枯后连续7天处死大鼠，测定其肺、肝、肾和血清中的胶原蛋白脯氨酰羟化酶活性。肝脏中的酶活性最初下降，然后恢复正常，肾脏中未发现变化。相比之下，肺酶水平升高了5倍，在第5天达到最大值。血清活性也出现了平行升高。这些酶升高的开始与肺泡细胞增殖的早期组织学表现相对应。
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