Zhang Zunwu
Norfolk and Norwich University Hospital, University of East Anglia, Colney Lane, Norwich NR4 7UY, UK.
J Gastrointest Cancer. 2007;38(1):38-45. doi: 10.1007/s12029-008-9015-1.
Although controversial, clinicians generally consider patients who present with gastric ulcer to have an increased risk of gastric cancer, while the risk for patients with duodenal ulcer is reduced in comparison with that of the general population. Infection with Helicobacter pylori and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are the major causes for peptic ulcers, but their roles in relation to the risk of gastric cancer in patients with peptic ulcer may be different.
This article reviewed existing literature to assess our understanding of the risk of gastric cancer in patients with gastric and duodenal ulcers more than 25 years after the discovery of H. pylori and also examined whether gastric ulcers induced by NSAID carry a lower risk of gastric cancer as compared to those induced by H. pylori infection or other causes.
尽管存在争议，但临床医生通常认为，患胃溃疡的患者患胃癌的风险增加，而十二指肠溃疡患者的风险与普通人群相比有所降低。幽门螺杆菌感染和使用非甾体抗炎药（NSAIDs）是消化性溃疡的主要病因，但它们在消化性溃疡患者患胃癌风险方面的作用可能有所不同。
本文回顾了现有文献，以评估自发现幽门螺杆菌25多年以来，我们对胃溃疡和十二指肠溃疡患者患胃癌风险的理解，并探讨与幽门螺杆菌感染或其他原因所致胃溃疡相比，NSAIDs所致胃溃疡的胃癌风险是否更低。
