Kuipers E J
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Gut. 2006 Sep;55(9):1217-21. doi: 10.1136/gut.2005.090514.
Proton pump inhibitors (PPIs) are very effective in maintaining symptomatic and endoscopic remission of acid peptic disorders, such as gastro-oesophageal reflux disease. Side effects with respect to function and morphology of the gastric mucosa are common. Helicobacter pylori eradication can partially prevent and reverse these effects without impairing PPI therapy for gastro-oesophageal reflux disease. This makes long term PPI treatment a safe therapy for patients with acid peptic disorders. The potential side effects of such therapy are discussed here.
质子泵抑制剂(PPIs)在维持酸相关性疾病(如胃食管反流病)的症状缓解和内镜下缓解方面非常有效。关于胃黏膜功能和形态的副作用很常见。根除幽门螺杆菌可以部分预防和逆转这些影响,同时不影响PPIs治疗胃食管反流病。这使得长期使用PPI治疗对酸相关性疾病患者来说是一种安全的治疗方法。本文将讨论这种治疗的潜在副作用。