Okosun Ike S
Institute of Public Health, College of Health and Human Sciences, Georgia State University, Atlanta, Georgia 30303-6879, USA.
Metab Syndr Relat Disord. 2008 Dec;6(4):289-97. doi: 10.1089/met.2008.0040.
Although elevated C-reactive protein (CRP) and abdominal obesity (AO) are associated with metabolic syndrome, their connection is unclear. The aim of this study was to determine the impact of AO on the association of CRP with metabolic syndrome.
Data (n = 6270) from the 2005-2006 U.S. National Health and Nutrition Examination Survey were used in this investigation. The impact of AO on the association of CRP with metabolic syndrome was determined using logistic regression analysis. In the regression model, statistical adjustments were made for age, sex, race/ethnicity, alcohol intake, smoking, education, and respiratory and inflammatory diseases.
Overall, elevated CRP (odds ratio [OR] = 1.38; 95% confidence interval [CI], 1.10-1.73) and AO (OR = 2.71; 95% CI, 1.93-3.80) were associated with increased odds of metabolic syndrome, adjusting for age, sex, race/ethnicity, alcohol intake, smoking, education, and respiratory and inflammatory diseases. In men, CRP (OR = 1.45; 95% CI, 1.04-2.03) and AO (OR = 2.03; 95% CI, 1.16-3.54) were associated with increased odds of metabolic syndrome. The corresponding values in women were 1.35 (95% CI, 1.05-1.86) and 2.94 (95% CI, 1.91-4.53), respectively. Overall, adjustment for AO was associated with 10.1% reduction in the association of CRP with metabolic syndrome. The analogous values for men and women were 4.8% and 14.1%, respectively.
In multivariate logistic regression analysis, CRP was associated with reduced risk of metabolic syndrome adjusting for AO independently of potential confounders, thus confirming once again the importance of weight reduction for the management of metabolic syndrome. Weight reduction programs or other interventions targeted specifically at abdominal regions may help to alleviate risk of metabolic syndrome.
尽管高敏C反应蛋白（CRP）升高和腹型肥胖（AO）与代谢综合征相关，但其联系尚不清楚。本研究旨在确定AO对CRP与代谢综合征之间关联的影响。
本研究使用了2005 - 2006年美国国家健康与营养检查调查的数据（n = 6270）。采用逻辑回归分析确定AO对CRP与代谢综合征之间关联的影响。在回归模型中，对年龄、性别、种族/民族、酒精摄入量、吸烟情况、教育程度以及呼吸和炎症性疾病进行了统计调整。
总体而言，在对年龄、性别、种族/民族、酒精摄入量、吸烟情况、教育程度以及呼吸和炎症性疾病进行调整后，CRP升高（比值比[OR]=1.38；95%置信区间[CI]，1.10 - 1.73）和AO（OR = 2.71；95% CI，1.93 - 3.80）与代谢综合征发生几率增加相关。在男性中，CRP（OR = 1.45；95% CI，1.04 - 2.03）和AO（OR = 2.03；95% CI，1.16 - 3.54）与代谢综合征发生几率增加相关。女性的相应值分别为1.35（95% CI，1.05 - 1.86）和2.94（95% CI，1.91 - 4.53）。总体而言，对AO进行调整后，CRP与代谢综合征之间的关联降低了10.1%。男性和女性的类似值分别为4.8%和14.1%。
在多变量逻辑回归分析中，调整AO后，CRP与代谢综合征风险降低相关，且独立于潜在混杂因素，这再次证实了减轻体重对代谢综合征管理的重要性。针对腹部区域的减重计划或其他干预措施可能有助于降低代谢综合征风险。
