Hillman Andrew J, Lohsoonthorn Vitool, Hanvivatvong Orrawadee, Jiamjarasrangsi Wiroj, Lertmaharit Somrat, Williams Michelle A
Department of Epidemiology, Multidisciplinary International Research Training Program, University of Washington School of Public Health, Seattle, Washington, USA.
Asian Biomed (Res Rev News). 2010 Jun;4(3):385-393.
To investigate the association of high sensitivity C-reactive protein (hsCRP) concentrations and metabolic syndrome among Thai adults. METHODS: This cross-sectional study is comprised of 467 Thai participants (209 men and 258 women) receiving annual health check-up. Spearman's rank correlation coefficients were used to assess associations of metabolic parameters (age, waist circumference, blood pressure, triglycerides, HDL-C, fasting plasma glucose, fasting insulin and uric acid) with hsCRP concentrations for men and women, respectively. Multivariable logistic regression procedures were used to estimate the risk (odds ratios [OR] and 95% confidence intervals [95% CI]) of metabolic syndrome according to low, moderate and high hsCRP concentrations (<1.0, 1.0-3.0 and >3.0 mg/l, respectively). RESULTS: Measures of adiposity and fasting insulin were positively and significantly correlated with hsCRP concentrations among women with and without metabolic syndrome. Similar associations were observed among men without metabolic syndrome. After controlling for confounders, moderately elevated hsCRP concentrations were associated with a 2.38-fold increased risk of metabolic syndrome (OR=2.38, 95% CI: 1.20-4.72) among men. Men with high hsCRP concentrations had a 5.45-fold increased risk of metabolic syndrome (OR=5.45, 95% CI: 2.24-13.27) when compared with those who had low hsCRP concentrations. The corresponding odds ratios for women with moderately elevated and high hsCRP concentrations were 4.92 (OR=4.92, 95% CI: 2.34-10.35) and 11.93 (OR=11.93, 95% CI: 5.54-25.72), respectively. CONCLUSIONS: These findings are consistent with the literature suggesting a role of hsCRP as a biomarker for metabolic syndrome.
探讨泰国成年人中高敏C反应蛋白（hsCRP）浓度与代谢综合征之间的关联。方法：这项横断面研究包括467名接受年度健康检查的泰国参与者（209名男性和258名女性）。分别采用Spearman等级相关系数评估男性和女性的代谢参数（年龄、腰围、血压、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、空腹胰岛素和尿酸）与hsCRP浓度之间的关联。采用多变量逻辑回归程序，根据hsCRP浓度低、中、高（分别为<1.0、1.0 - 3.0和>3.0 mg/l）估计代谢综合征的风险（比值比[OR]和95%置信区间[95%CI]）。结果：在患有和未患有代谢综合征的女性中，肥胖指标和空腹胰岛素与hsCRP浓度呈正相关且具有统计学意义。在未患有代谢综合征的男性中也观察到类似的关联。在控制混杂因素后，hsCRP浓度中度升高与男性代谢综合征风险增加2.38倍相关（OR = 2.38，95%CI：1.20 - 4.72）。与hsCRP浓度低的男性相比，hsCRP浓度高的男性患代谢综合征的风险增加5.45倍（OR = 5.45，95%CI：2.24 - 13.27）。hsCRP浓度中度升高和高的女性的相应比值比分别为4.92（OR = 4.92，95%CI：2.34 - 10.35）和11.93（OR = 11.93，95%CI：5.54 - 25.72）。结论：这些发现与文献一致，表明hsCRP作为代谢综合征生物标志物的作用。
