沙蟾内酯 A⁻D，来源于一种韩国海绵的海生海绵Scalarane 倍半萜，具有γ-内酰胺部分。

Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea.

The Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Science, Seoul National University, NS-80, Seoul 08826, Korea.

Molecules. 2018 Dec 3;23(12):3187. doi: 10.3390/molecules23123187.

Intensive study on the chemical components of a Korean marine sponge, sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A⁻D (⁻). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A⁻D (⁻) possess a scalarane carbon skeleton with a rare structural feature of a γ-lactam moiety within the molecules. Scalalactams A and B ( and ) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D ( and ) possess a phenethyl group at the lactam ring moiety. Scalalactams A⁻D (⁻) did not show FXR antagonistic activity nor cytotoxicity up to 100 μM.

对韩国海洋海绵 sp. 的化学成分进行了深入研究，分离得到了四个新的重排甾烷倍半萜内酯，分别为 scalalactams A⁻D（⁻）。通过分析包括 1D 和 2D-NMR 以及 MS 数据在内的光谱数据，阐明了它们的化学结构。Scalalactams A⁻D（⁻）具有重排甾烷碳骨架，分子内具有罕见的γ-内酰胺部分结构特征。Scalalactams A 和 B（和）在内酯环上具有扩展的异丙基链，而 scalalactams C 和 D（和）在内酯环部分具有苯乙基基团。Scalalactams A⁻D（⁻）在高达 100 μM 的浓度下均没有表现出 FXR 拮抗活性和细胞毒性。