Nakagishi Yoshinori, Morimoto Noriko, Fujita Masanori, Ozeki Yuichi, Maehara Tadaaki, Kikuchi Makoto, Morimoto Yuji
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan.
Photochem Photobiol. 2009 May-Jun;85(3):714-8. doi: 10.1111/j.1751-1097.2008.00472.x. Epub 2008 Nov 19.
It is difficult to treat patients with acquired airway stenosis, and the quality of life of such patients is therefore lowered. We have suggested the application of photodynamic therapy (PDT) as a new treatment for airway stenosis and have determined the efficacy of PDT in animal disease models using a second-generation photosensitizer with reduced photosensitivity. An airway stenosis rabbit model induced by scraping of the tracheal mucosa was administered NPe6 (5 mg kg(-1)), and the stenotic lesion was irradiated with 670 nm light emitted from a cylindrical diffuser tip at 60 J cm(-2) under bronchoscopic monitoring. PDT using NPe6 improved airway stenosis (P = 0.043) and respiratory stridor. A significant prolongation of survival time was seen in the PDT-treated animals compared to that in the untreated animals (P = 0.025) and 44% of the treated animals achieved long-term survival (>60 days). In conclusion, PDT using NPe6 is effective for improvement in airway stenosis.
治疗获得性气道狭窄患者较为困难，因此这类患者的生活质量会降低。我们已建议将光动力疗法（PDT）作为气道狭窄的一种新治疗方法，并使用光敏性降低的第二代光敏剂确定了PDT在动物疾病模型中的疗效。对通过刮除气管黏膜诱导的气道狭窄兔模型给予NPe6（5 mg kg(-1)），并在支气管镜监测下，用来自圆柱形扩散器尖端的670 nm光以60 J cm(-2)的剂量照射狭窄病变部位。使用NPe6的PDT改善了气道狭窄（P = 0.043）和呼吸喘鸣。与未治疗的动物相比，接受PDT治疗的动物存活时间显著延长（P = 0.025），44%的治疗动物实现了长期存活（>60天）。总之，使用NPe6的PDT对改善气道狭窄有效。
