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The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci.

作者信息

Parmentier M, Passage E, Vassart G, Mattei M G

机构信息

IRIBHN, Université libre de Bruxelles, Belgium.

出版信息

Cytogenet Cell Genet. 1991;57(1):41-3. doi: 10.1159/000133111.

DOI:10.1159/000133111
PMID:1906795
Abstract

The genes encoding calbindin D28k (CALB1) and calretinin (CALB2), two closely related calcium-binding proteins, were mapped by in situ hybridization to the 8q21.3----q22.1 and 16q22----q23 regions of the human genome, respectively. These localizations match the chromosomal regions where the carbonic anhydrase isozyme gene cluster (CA1, CA2, CA3) and the related gene CA7 have been described, respectively. This suggests a common duplication o the calbindin/calretinin and the carbonic anhydrase ancestral genes.

摘要

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