Alavian Seyed-Moayed, Izadi Morteza, Zare Ali-Akbar, Lankarani Maryam Moghani, Assari Shervin, Vardi Mohammad-Mahdi
Baqiyatallah Research Center for Gastroenterology and Liver Disease, Tehran, Iran.
Spec Care Dentist. 2008 Nov-Dec;28(6):265-70. doi: 10.1111/j.1754-4505.2008.00052.x.
Hepatitis B is an infectious disease to which dentists are susceptible. The main aim of this study was to determine the level of antibody titer and immunity in vaccinated Iranian general dentists. A total of 861 general dentists were invited to participate in this study; 598 persons who could recall their history of vaccination and consented to have blood samples taken were recruited. Demographic and work-related data were recorded, and anti-Hepatitis B surface antigen (anti-HBs-Ag) evaluations were measured using the enzyme-linked immunosorbent assay (ELISA). Of the 598 participants, 35 (5.9%) were nonimmune (anti-HBs <10 IU/l), 101 (16.9%) were relatively immune (anti-HBs = 10-99 IU/l), and 462 (77.3%) were completely immune (anti-HBs > or =100 IU/l). Only 218 (36.5%) of the dentists knew their HBs antibody titer. Fourteen (2.3%) persons reported receiving one dose and 65 (10.9%) had received two doses. The number of those who had received the three recommended doses totaled 519 (86.8%), 491 (82.1%) of them receiving their vaccine on schedule. Age, city, pack-years of smoking, years of smoking, and the interval between the last vaccination and the commencement of the study had a significant relationship to the antibody titer level, whereas sex, marital status, place of practice, smoking, and vaccination schedule were not related. Only 36.5% of the general dentists had checked their antibody titer. We, therefore, recommend that dentists, as a potential high-risk group, should know their level of anti-HBs antibody titer so that those who require revaccination can get treatment.
乙型肝炎是一种牙医易感染的传染病。本研究的主要目的是确定接种疫苗的伊朗普通牙医的抗体滴度水平和免疫力。共有861名普通牙医受邀参与本研究;招募了598名能够回忆起其疫苗接种史并同意采集血样的人员。记录了人口统计学和工作相关数据,并使用酶联免疫吸附测定法(ELISA)测量抗乙型肝炎表面抗原(抗-HBs-Ag)。在598名参与者中,35人(5.9%)无免疫力(抗-HBs<10 IU/l),101人(16.9%)有相对免疫力(抗-HBs = 10-99 IU/l),462人(77.3%)完全免疫(抗-HBs>或 =100 IU/l)。只有218名(36.5%)牙医知道他们的HBs抗体滴度。14人(2.3%)报告接种了一剂,65人(10.9%)接种了两剂。接种了三剂推荐剂量疫苗的人数总计519人(86.8%),其中491人(82.1%)按时接种了疫苗。年龄、城市、吸烟包年数、吸烟年数以及最后一次接种与研究开始之间的间隔与抗体滴度水平有显著关系,而性别、婚姻状况、执业地点、吸烟情况和疫苗接种时间表则无关。只有36.5%的普通牙医检查过他们的抗体滴度。因此,我们建议,作为潜在的高危人群,牙医应该了解自己的抗-HBs抗体滴度水平,以便那些需要重新接种疫苗的人能够得到治疗。