食用富含核桃酱肉类的高心血管疾病风险个体的血小板聚集、类花生酸生成及血栓形成率。一项交叉、安慰剂对照研究。

Platelet aggregation, eicosanoid production and thrombogenic ratio in individuals at high cardiovascular risk consuming meat enriched in walnut paste. A crossover, placebo-controlled study.

作者信息

Canales Amaia, Bastida Sara, Librelottto Josana, Nus Meritxell, Sánchez-Muniz Francisco J, Benedi Juana

机构信息

Departamento de Nutrición y Bromatología I (Nutrición), Universidad Complutense de Madrid, Madrid E-28040, Spain.

出版信息

Br J Nutr. 2009 Jul;102(1):134-41. doi: 10.1017/S000711450813361X. Epub 2008 Dec 10.

DOI:10.1017/S000711450813361X

PMID:19068151

Abstract

Walnut consumption produces beneficial cardiovascular effects. The aim of the present study is to compare the effects of meat enriched in walnut paste (WM) and low-fat meat (LM) consumptions on platelet aggregation, plasma thromboxane A2 (TXA2, measured as TXB2), prostacyclin I2 (PGI2, as 6-keto-PGF1alpha) and the thrombogenic ratio (TXB2/6-keto-PGF1alpha) in volunteers at high CVD risk. Twenty-two adults were placed on a random, non-blinded crossover study involving two test periods (five portions WM/week for 5 week; five portions LM/week for 5 week) separated by a 4- to 6-week washout period. The participants were asked to complete a diet record throughout the study. Platelet aggregation, plasma TXB2, 6-keto-PGF1alpha production and the TXB2/6-keto-PGF1alpha ratio were determined at baseline and at weeks 3 and 5 for the two dietary periods. The WM diet contains a lower SFA content, a higher concentration of PUFA and a more favourable n-6/n-3 ratio than the LM diet. Significant time x treatment interactions were observed for TXB2 (P = 0.048) and the TXB2/6-keto-PGF1alpha ratio (P = 0.028). The WM diet significantly increased the level of 6-keto-PGF1alpha (P = 0.037) and decreased the TXB2/6-keto-PGF1alpha ratio (P = 0.048). At week 5, significant differences (P < 0.05) between treatments were found for maximum aggregation rate, TXB2 values and the TXB2/6-keto-PGF1alpha ratio. The effects on TXB2 and the TXB2/6-keto-PGF1alpha ratio were time-course dependent (P = 0.019 and 0.011, respectively). The WM and LM diets reduced TXB2 levels most (P = 0.050) in obese individuals, while the TXB2/6-keto-PGF1alpha ratio decreased most (P = 0.066) in volunteers whose serum cholesterol levels were > or = 2200 mg/l. The WM diet should be considered a functional meat because it improves the thrombogenic status mainly in individuals with high-cholesterol levels or high BMI.

摘要

食用核桃对心血管有益。本研究旨在比较食用富含核桃酱的肉类（WM）和低脂肉类（LM）对高心血管疾病风险志愿者血小板聚集、血浆血栓素A2（TXA2，以TXB2衡量）、前列环素I2（PGI2，以6-酮-PGF1α衡量）及血栓形成比值（TXB2/6-酮-PGF1α）的影响。22名成年人参与了一项随机、非盲交叉研究，该研究包括两个试验期（每周食用五份WM，共5周；每周食用五份LM，共5周），两个试验期之间有4至6周的洗脱期。在整个研究过程中，要求参与者完成饮食记录。在两个饮食期的基线以及第3周和第5周测定血小板聚集、血浆TXB2、6-酮-PGF1α生成量及TXB2/6-酮-PGF1α比值。与LM饮食相比，WM饮食的饱和脂肪酸（SFA）含量更低，多不饱和脂肪酸（PUFA）浓度更高，n-6/n-3比值更有利。观察到TXB2（P = 0.048）和TXB2/6-酮-PGF1α比值（P = 0.028）存在显著的时间×处理交互作用。WM饮食显著提高了6-酮-PGF1α水平（P = 0.037），并降低了TXB2/6-酮-PGF1α比值（P = 0.048）。在第5周时，发现处理之间在最大聚集率、TXB2值和TXB2/6-酮-PGF1α比值方面存在显著差异（P < 0.05）。对TXB2和TXB2/6-酮-PGF1α比值的影响呈时间依赖性（分别为P = 0.019和0.011）。WM和LM饮食在肥胖个体中使TXB2水平降低最多（P = 0.050），而在血清胆固醇水平≥2200 mg/l的志愿者中，TXB2/6-酮-PGF1α比值降低最多（P = 0.066）。WM饮食应被视为一种功能性肉类，因为它主要改善了高胆固醇水平或高体重指数个体的血栓形成状态。