Daneshbod Yahya, Khademi Bijan, Kadivar Maryam, Ganjei-Azar Parvin
Department of Cytopathology and Hematopathology, Dr. Daneshbod Pathology Laboratory, and Departanent of Otolaryngology, Head and Neck Surgery, Shiraz School of Medicine, Shiraz, Iran.
Acta Cytol. 2008 Nov-Dec;52(6):671-80. doi: 10.1159/000325620.
To report on multinucleated giant cells (MNGCs) in salivary fine needle aspiration (FNA).
The cytologic reports of salivary gland region FNA during a 10-year period was searched using the keyword giant cell in the final diagnosis or microscopic description. Cases with foreign body-type giant cells secondary to previous biopsy or FNA were excluded. Histologic correlations and immunohistochemical staining for CD68, CK, EMA, S100, HMB45 and CD1a were performed on selected cases.
Twenty-six aspiration smears containing MNGCs were identified from 1040 salivary gland FNAs (2.5%). MNGCs were seen in some reactive or inflammatory conditions, benign neoplasms and malignant neoplasms. By type of MNGC, the salivary lesions were categorized in 3 groups: those with foreign body type, osteoclast type and tumor giant cells.
MNGCs can be seen in a wide spectrum of salivary gland lesions ranging from reactive to benign and malignant. They are of nonepithelial origin or can be of true neoplastic nature in metastatic lesions.
报告涎腺细针穿刺活检（FNA）中的多核巨细胞（MNGC）。
使用关键词“巨细胞”在最终诊断或显微镜描述中检索10年间涎腺区域FNA的细胞学报告。排除既往活检或FNA继发异物型巨细胞的病例。对部分病例进行组织学对照及CD68、细胞角蛋白（CK）、上皮膜抗原（EMA）、S100、HMB45和CD1a的免疫组化染色。
在1040例涎腺FNA中，识别出26例含有MNGC的穿刺涂片（2.5%）。MNGC可见于一些反应性或炎症性病变、良性肿瘤和恶性肿瘤中。根据MNGC的类型，将涎腺病变分为3组：异物型、破骨细胞型和肿瘤巨细胞型。
MNGC可见于广泛的涎腺病变，从反应性病变到良性和恶性病变。它们起源于非上皮组织，或在转移性病变中具有真正的肿瘤性质。
