Adonis-Koffy L
Département mère-enfant, Service de pédiatrie-CHU de Yopougon Abidjan, Côte d'Ivoire.
Med Trop (Mars). 2008 Oct;68(5):545-8.
Severe malaria is a major cause of child morbidity and mortality in Sub-Saharan Africa. A frequent major complication of malarial infection is anemia. The WHO lists severe anemia as one of the 15 criteria for diagnosis of complicated malaria. Proper treatment of uncomplicated falciparum malaria is included among the strategies for preventing severe forms of malaria. Since 2000 it has been recommended that treatment of uncomplicated falciparum malaria be conducted with artemisinin-based combination therapy (ACT) as a way of protecting against emergence of Plasmodium resistance to artemisinin. Based on the etiopathogenic factors involved in development of anemia in children living in tropical regions and on the features of the different compounds used in ACT, the author of this study demonstrates the beneficial effect of these treatments on prevention of complicated forms of malaria in general and of malarial anemia in particular.
重症疟疾是撒哈拉以南非洲地区儿童发病和死亡的主要原因。疟疾感染常见的主要并发症是贫血。世界卫生组织将严重贫血列为复杂型疟疾诊断的15项标准之一。预防重症疟疾的策略包括对非复杂型恶性疟进行恰当治疗。自2000年以来，一直建议采用以青蒿素为基础的联合疗法（ACT）治疗非复杂型恶性疟，以防止疟原虫对青蒿素产生耐药性。基于热带地区儿童贫血发生的病因学因素以及ACT中所用不同化合物的特点，本研究的作者证明了这些治疗方法对预防一般复杂型疟疾，尤其是疟性贫血的有益效果。
