Uganda Malaria Surveillance Project, PO Box 7475, Kampala, Uganda.
Malar J. 2010 Mar 24;9:84. doi: 10.1186/1475-2875-9-84.
By 2008, the WHO Pesticide Evaluation Scheme (WHOPES) recommended five long-lasting insecticidal nets (LLINs) for the prevention of malaria: Olyset((R)), PermaNet 2.0((R)), Netprotect((R)), Duranet((R)) and Interceptor((R)). Field information is available for both Olyset(R) and PermaNet((R)), with limited data on the newer LLINs. To address this gap, a field evaluation was carried out to determine the acceptability and durability of Interceptor((R)) LLINs.
A one-year prospective field study was conducted in eight rural returnee villages in Liberia. Households were randomized to receive Interceptor((R)) LLINs or conventionally treated nets (CTNs). Primary outcomes were levels of residual alpha-cypermethrin measured by HPLC and participant utilization/acceptability of the ITNs.
A total of 398 nets were analysed for residual alpha-cypermethrin. The median baseline concentrations of insecticide were 175.5 mg/m2 for the Interceptor((R)) LLIN and 21.8 mg/m2 for the CTN. Chemical residue loss after a one year follow-up period was 22% and 93% respectively. Retention and utilization of nets remained high (94%) after one year, irrespective of type, while parasitaemia prevalence decreased from 29.7% at baseline to 13.6% during the follow up survey (p = < 0.001). Interview and survey data show perceived effectiveness of ITNs was just as important as other physical attributes in influencing net utilization.
Interceptor((R)) LLINs are effective and desirable in rural communities in Liberia. Consideration for end user preferences should be incorporated into product development of all LLINs in the future, in order to achieve optimum retention and utilization.
到 2008 年，世界卫生组织杀虫剂评价方案（WHOPES）推荐了 5 种长效杀虫蚊帐（LLINs）用于预防疟疾：Olyset(R)、PermaNet 2.0(R)、Netprotect(R)、Duranet(R)和Interceptor(R)。已经有关于 Olyset(R)和 PermaNet(R)的实地信息，而关于较新的 LLINs 的数据有限。为了弥补这一差距，进行了实地评估，以确定 Interceptor(R)LLINs 的可接受性和耐用性。
在利比里亚的 8 个农村归国者村庄进行了为期一年的前瞻性实地研究。将家庭随机分配接受 Interceptor(R)LLINs 或常规处理的蚊帐。主要结果是通过 HPLC 测量的残留α-氯菊酯水平和参与者对 ITN 的利用/可接受性。
共分析了 398 个蚊帐的残留α-氯菊酯。Interceptor(R)LLIN 的基线昆虫剂浓度中位数为 175.5mg/m2，而 CTN 为 21.8mg/m2。一年随访期后，化学残留损失分别为 22%和 93%。一年后，无论类型如何，蚊帐的保留率和利用率仍然很高（94%），而寄生虫血症患病率从基线时的 29.7%降至随访期间的 13.6%（p<0.001）。访谈和调查数据表明，ITN 的感知效果与其他物理属性一样，对影响蚊帐利用率至关重要。
Interceptor(R)LLINs 在利比里亚农村社区是有效且理想的。在未来，所有 LLINs 的产品开发都应考虑最终用户的偏好，以实现最佳的保留率和利用率。
