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[热带人群中布鲁氏菌属细菌血清抗体的流行情况]

[Prevalence of serum antibodies for the bacterium Brucella sp. in a tropical human population].

作者信息

Chanto Grettel, Rojas Norman, Ching Adrián, Zúñiga Ronald, Castro Edith, Chaverri Sonia, Asenjo Angelina, Campos Elena

机构信息

Centro Nacional de Referencia en Bacteriología, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Cartago, Costa Rica.

出版信息

Rev Biol Trop. 2007 Jun;55(2):385-91.

Abstract

Prevalence of serum antibodies for the bacterium Brucella sp. in a tropical human population. Brucellosis is a systemic bacterial disease that can last years if not treated properly. The laboratory diagnosis is made by serological tests or isolation of the agent. We studied the prevalence of antibodies against Brucella sp. in inhabitants of rural communities of Cartago, Costa Rica, who are dedicated mainly to dairy cattle activities. We analyzed 714 representative samples with the Rose Bengal plate agglutination test (RBT) and the standard agglutination test in microplate (SAT). The overall prevalence was 0.87%. No seroconversion was demonstrated for seropositive individuals. Even though 71% of the population mentioned consuming non-pasteurized milk, no statistically significant association was found (1.09 %, IC 0.30-2.77) between milk consumption and the presence of antibodies suggestive of infection by Brucella sp. As a brucellosis high-risk population, the absence of symptoms in the population agrees with the observed titers of antibodies, suggesting a low previous exposure to the agent.

摘要

热带人群中布鲁氏菌属细菌血清抗体的流行情况。布鲁氏菌病是一种全身性细菌疾病,若治疗不当可持续数年。实验室诊断通过血清学检测或病原体分离进行。我们研究了哥斯达黎加卡塔戈农村社区居民中抗布鲁氏菌属抗体的流行情况,这些居民主要从事奶牛养殖活动。我们用玫瑰红平板凝集试验(RBT)和微量板标准凝集试验(SAT)分析了714份代表性样本。总体流行率为0.87%。血清阳性个体未出现血清学转换。尽管71%的人群提到饮用过生牛奶,但在饮用牛奶与存在提示布鲁氏菌属感染的抗体之间未发现统计学上的显著关联(1.09%,95%置信区间0.30 - 2.77)。作为布鲁氏菌病高危人群,该人群无症状与观察到的抗体滴度相符,表明既往接触该病原体的情况较少。

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