Nusier Mohamad K, Bataineh Hameed N, Daradka Haytham M
Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid 22110, Jordan.
Pak J Biol Sci. 2007 Aug 15;10(16):2728-31. doi: 10.3923/pjbs.2007.2728.2731.
Ingestion of propranolol at 10 and 15 mg kg(-1) body weight for 35 days by adult male mice was investigated for its effects on fertility. Body weight and absolute and relative testes weights were reduced and the average weights of epididymis, ventral prostate and seminal vesicle decreased significantly. A significant decline of spermatogenesis in testes due to a decrease in the number of primary, secondary spermatocytes and spermatids in the treatment group 2 (15 mg kg(-1)) is attributed to a significant decrease in testosterone, LH and FSH. Sperm motility and density were also significantly decreased in the cauda epididymis and in the testes of group 2 treated male mice. In addition, the treatment markedly increased the number of fetal resorptions in female mice impregnated by the group 2 males, thereby reducing their fertility.
研究了成年雄性小鼠以10毫克/千克和15毫克/千克体重的剂量摄入普萘洛尔35天对生育能力的影响。体重以及绝对和相对睾丸重量均降低，附睾、腹侧前列腺和精囊的平均重量显著下降。治疗组2（15毫克/千克）睾丸中的精子发生显著下降，原因是初级、次级精母细胞和精子细胞数量减少，这归因于睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）的显著降低。在治疗组2的雄性小鼠的附睾尾部和睾丸中，精子活力和密度也显著降低。此外，该治疗显著增加了由治疗组2的雄性小鼠使雌性小鼠受孕后的胎儿吸收数量，从而降低了它们的生育能力。
