一些4-取代嘧啶及稠合嘧啶的合成与生物活性
Synthesis and biological activity of some 4-substituted pyrimidines and fused pyrimidines.
作者信息
el-Bahaie S, el-Deeb A, Assy M C
机构信息
Chemistry Department, Faculty of Science, Zagazig University, Egypt.
出版信息
Pharmazie. 1991 Jan;46(1):26-8.
PMID:1907010
Abstract
The synthesis of 4-beta-cyanoethylthiopyrimidine 2 and 4-chloropyrimidine 8a was chieved from 4-mercapto-5-acetylpyrimidine (1a). Also the synthesis of thienopyrimidine-7,7-dioxide 6, 4-arylaminopyrimidines 9a-e, 4-alkoxypyrimidines 11a, b, pyrimidoquinazoline 10, thienopyrimidines 19a, b and tetrazolopyrimidine 18 was described.
摘要
4-β-氰基乙硫基嘧啶2和4-氯嘧啶8a是由4-巯基-5-乙酰基嘧啶（1a）合成的。此外，还描述了噻吩并嘧啶-7,7-二氧化物6、4-芳基氨基嘧啶9a-e、4-烷氧基嘧啶11a、b、嘧啶并喹唑啉10、噻吩并嘧啶19a、b和四唑并嘧啶18的合成。
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