杂环合成中的氨基唑类。一些具有药学意义的新型嘧啶并苯并咪唑、吡唑啉酮吡啶以及三唑并、四唑并和吡唑并嘧啶的合成。
Aminoazoles in heterocyclic synthesis. Synthesis of some new pyrimidobenzimidazoles and pyrazolonopyridines as well as triazolo-, tetrazolo- and pyrazolo-pyrimidines of pharmaceutical interest.
作者信息
Kandeel E M, Hammouda M, Metwally M A
机构信息
Chemistry Department, Faculty of Science, Mansoura University, Egypt.
出版信息
Boll Chim Farm. 1996 Apr;135(4):232-5.
The reactivity of 3-cinnamoylindole, 3-cinnamoylantipyrine and 1-(3-methyl-1-phenyl-5-pyrazolon-4 yl)-4-antipyrin-4-yl)-prop-2-ene-1- one(la-c) towards 2-aminobenzimidazole, 3-amino-1,2,4-triazole, 5-aminotetrazole monohydrate, 5-amino-3-phenylpyrazole and 3-amino-1-phenyl-2-pyrazolin-5-one to give the fused heterocycles 2a-c, 4a,b, 5a,b, 8a,b, and 10a-c has been investigated. Structures of the synthesized compounds were confirmed by both the analytical and the spectral data (IR, UV and 1H NMR).
研究了3-肉桂酰基吲哚、3-肉桂酰基安替比林和1-(3-甲基-1-苯基-5-吡唑啉酮-4-基)-4-安替比林-4-基)-丙-2-烯-1-酮(la-c)与2-氨基苯并咪唑、3-氨基-1,2,4-三唑、5-氨基四唑一水合物、5-氨基-3-苯基吡唑和3-氨基-1-苯基-2-吡唑啉-5-酮反应生成稠合杂环2a-c、4a,b、5a,b、8a,b和10a-c的情况。通过分析数据和光谱数据(红外光谱、紫外光谱和1H核磁共振谱)确定了合成化合物的结构。
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