Pourjafar M, Aghbolaghi P A, Shakhse-Niaie M
School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Pak J Biol Sci. 2007 Aug 15;10(16):2772-4. doi: 10.3923/pjbs.2007.2772.2774.
Garlic ability to reduce lead burden in body tissues before and during chronic lead toxicity was studied. Eighty mice were divided into 8 groups. Group D received placebo. Groups A1, A2 and A3, respectively received 500, 250 and 125 mg kg(-1) day garlic and Groups B1, B2 and B3, respectively 1/4, 1/8 and 1/16 garlic tablet kg(-1) day in first four weeks and in second four weeks they received 5 mg kg(-1) day lead acetate plus garlic or garlic tablet. Group C received placebo in first four weeks and in second four weeks they received 5 mg kg(-1) day lead acetate and placebo. Reduction in lead burden of kidney, liver, bone and blood (except for group A3) in experimental groups was significant compared with group C (p<0.05). Results showed that fresh garlic extract and garlic tablet had almost same effects on lead reduction in tissues.
研究了大蒜在慢性铅中毒之前和期间降低机体组织中铅负荷的能力。80只小鼠被分为8组。D组接受安慰剂。A1、A2和A3组分别接受500、250和125毫克/千克·天的大蒜，B1、B2和B3组在前四周分别接受1/4、1/8和1/16片大蒜/千克·天，在后四周接受5毫克/千克·天的醋酸铅加大蒜或大蒜片。C组在前四周接受安慰剂，在后四周接受5毫克/千克·天的醋酸铅和安慰剂。与C组相比，实验组肾脏、肝脏、骨骼和血液（A3组除外）的铅负荷降低显著（p<0.05）。结果表明，新鲜大蒜提取物和大蒜片对组织中铅的降低作用几乎相同。
