Martinez-Garcia F, Martínez-Ruiz F, Vicente I, Peñafiel R, Cremades A
Department of Physiology and Pharmacology, School of Medicine, University of Murcia, Spain.
Eur J Pharmacol. 1995 Oct 6;293(3):271-5. doi: 10.1016/0926-6917(95)00029-1.
The effect of environmental temperature on lead accumulation in tissues of mice repeatedly treated with lead acetate (2 mg/kg per day and 5 mg/kg per day) for 3 or 6 weeks was studied. In blood, kidney and liver, the amount of lead accumulated after 3 weeks of treatment was markedly higher in animals exposed to 22 degrees C than those maintained at 35 degrees C. Conversely, when the treatment was extended to 6 weeks, lead concentrations in the liver and kidney were equal or higher respectively, in the mice exposed to 35 degrees C. In the brain, lead concentration was lower than that found in kidney and liver and it was independent of dose and ambient temperature of lead being higher at 35 degrees C than at 22 degrees C. These results demonstrate that environmental temperature influences the amount of lead accumulated in some rodent tissues, and that the duration of the treatment modifies the effect produced by temperature, suggesting that the changes elicited during the period of acclimation to the hot environment could be responsible for these findings.
研究了环境温度对用醋酸铅（每天2毫克/千克和每天5毫克/千克）反复处理3周或6周的小鼠组织中铅蓄积的影响。在血液、肾脏和肝脏中，暴露于22摄氏度的动物在处理3周后蓄积的铅量明显高于维持在35摄氏度的动物。相反，当处理延长至6周时，暴露于35摄氏度的小鼠肝脏和肾脏中的铅浓度分别相等或更高。在大脑中，铅浓度低于在肾脏和肝脏中发现的浓度，并且它与剂量和环境温度无关，35摄氏度时的铅浓度高于22摄氏度时的铅浓度。这些结果表明，环境温度会影响某些啮齿动物组织中蓄积的铅量，并且处理持续时间会改变温度产生的影响，这表明在适应炎热环境期间引发的变化可能是这些发现的原因。
