17α-和17β-勃地酮17-葡萄糖醛酸苷：通过¹H和¹³C核磁共振进行合成及完整表征
17alpha- and 17beta-boldenone 17-glucuronides: synthesis and complete characterization by 1H and 13C NMR.
作者信息
Casati Silvana, Ottria Roberta, Ciuffreda Pierangela
机构信息
Dipartimento di Scienze Precliniche LITA Vialba, Università degli Studi di Milano, Via G.B. Grassi, 74-20157 Milano, Italy.
出版信息
Steroids. 2009 Feb;74(2):250-5. doi: 10.1016/j.steroids.2008.11.012. Epub 2008 Nov 24.
Boldenone is an androgenic anabolic steroid intensively used for growth promoting purposes in animals destined for meat production and as a performance enhancer in athletics. Therefore its use is officially banned either in animals intended for consumption or in humans. Because most anabolic steroids are completely metabolized and usually no parent steroid is excreted, metabolite identification is crucial to detect the illegal use of anabolic steroids either in humans or in livestock. 17alpha- and 17beta-boldenone 17-glucuronides were synthesized, purified and characterized in order to provide suitable standards for the identification and quantification of these metabolites.
勃地龙是一种雄激素类合成代谢类固醇，被大量用于促进供肉用动物的生长，以及作为运动员的性能增强剂。因此，它在供食用动物或人类中的使用被官方禁止。由于大多数合成代谢类固醇会被完全代谢，通常不会排泄出母体类固醇，所以代谢物鉴定对于检测人类或家畜中合成代谢类固醇的非法使用至关重要。为了提供用于鉴定和定量这些代谢物的合适标准品，合成、纯化并表征了17α-和17β-勃地龙17-葡糖苷酸。
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