Werner M J, Biro F M
Division of Adolescent Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229.
J Adolesc Health. 1991 Jun;12(4):326-8. doi: 10.1016/0197-0070(91)90008-a.
The objective of this study was to evaluate the effectiveness of urinary leukocyte esterase on random urine specimens as a screening test for chlamydial and gonococcal urethral infections in asymptomatic males. Random urine specimens were obtained on 106 consecutive asymptomatic adolescent males during intake physical examination at a residential vocational training program. Results of urinary leukocyte esterase were compared to those of urethral cultures for Chlamydia trachomatis and Neisseria gonorrhoeae. Five subjects had positive chlamydia cultures, three subjects had positive gonococcal cultures, and one patient had positive cultures for both organisms. Sixteen subjects had leukocyte esterase tests reported as "trace" or greater. When compare to positive culture results for either Chlamydia or gonorrhea, urinary leukocyte esterase activity had a sensitivity of 78%, specificity of 91%, and positive predictive value of 44%. A random urine specimen for urinary leukocyte esterase activity is a cost-effective screening method for chlamydial and gonococcal urethral infections in asymptomatic adolescent males.
本研究的目的是评估随机尿液标本中尿白细胞酯酶作为无症状男性衣原体和淋菌性尿道感染筛查试验的有效性。在一个住宿职业培训项目的入学体检期间，对106名连续的无症状青少年男性采集了随机尿液标本。将尿白细胞酯酶的结果与沙眼衣原体和淋病奈瑟菌的尿道培养结果进行比较。5名受试者衣原体培养阳性，3名受试者淋菌培养阳性，1名患者两种病原体培养均阳性。16名受试者的白细胞酯酶试验报告为“微量”或更高。与衣原体或淋病的阳性培养结果相比，尿白细胞酯酶活性的敏感性为78%，特异性为91%，阳性预测值为44%。随机尿液标本检测尿白细胞酯酶活性是无症状青少年男性衣原体和淋菌性尿道感染的一种经济有效的筛查方法。
