Rahman Md Saifur, Beever Warwick, Skov Steven, Boffa John
Collaborative Research Network for Mental Health in Rural and Regional Communities, The University of New England, Armidale, Australia.
Int J STD AIDS. 2014 Feb;25(2):138-44. doi: 10.1177/0956462413495670. Epub 2013 Jul 19.
To evaluate a leucocyte esterase test as a predictor of gonorrhoea or chlamydia in asymptomatic Aboriginal males at the Central Australian Aboriginal Congress Male Clinic (Ingkintja), first-void urine samples and clinical information were collected from consecutive asymptomatic males presenting to the Ingkintja in Alice Springs between March 2008 and December 2009. Urine was tested immediately with a leucocyte esterase test dipstick and then by polymerase chain reaction for gonorrhoea and chlamydia. Among the 292 specimens from asymptomatic males, 15.4% were positive for gonorrhoea or chlamydia. In this group, compared with polymerase chain reaction result for gonorrhoea or chlamydia, leucocyte esterase test alone and in combination with age ≤35 years showed sensitivities of 66.7% and 60%, specificities of 90.7% and 94.7%, positive predictive values of 56.6% and 67.5%, negative predictive values of 93.7% and 92.8% and the area under receiver operating characteristics curve values of 0.79 and 0.85, respectively. Leucocyte esterase tests can reasonably be used as a basis for immediate empirical treatment for gonorrhoea or chlamydia in asymptomatic central Australian Aboriginal men under 35 years of age.
为了评估白细胞酯酶检测作为澳大利亚中部原住民大会男性诊所（Ingkintja）无症状原住民男性淋病或衣原体感染预测指标的效果，于2008年3月至2009年12月期间，收集了连续到爱丽丝泉Ingkintja就诊的无症状男性的首次晨尿样本及临床信息。尿液立即用白细胞酯酶检测试纸条进行检测，然后通过聚合酶链反应检测淋病和衣原体。在292份无症状男性的样本中，15.4%的样本淋病或衣原体检测呈阳性。在该组中，与淋病或衣原体的聚合酶链反应结果相比，单独的白细胞酯酶检测以及结合年龄≤35岁时，敏感性分别为66.7%和60%，特异性分别为90.7%和94.7%，阳性预测值分别为56.6%和67.5%，阴性预测值分别为93.7%和92.8%，受试者工作特征曲线下面积值分别为0.79和0.85。白细胞酯酶检测可合理地用作35岁以下无症状澳大利亚中部原住民男性淋病或衣原体感染即时经验性治疗的依据。
