急性硅蛋白沉着症

Xipell J M, Ham K N, Price C G, Thomas D P

Thorax. 1977 Feb;32(1):104-11. doi: 10.1136/thx.32.1.104.

A case of alveolar lipoproteinosis associated with silicosis is reported. A 58-year-old man had been exposed to silica for seven years and died three years after the onset of symptoms. Light microscopy of biopsy and necropsy material showed small silicotic nodules, silica particles, and alveolar lipoproteinosis, and ultrastructural studies were performed to define changes in alveolar epithelium and macrophages. The case provides a further example of alveolar lipoproteinosis developing as a response of the lung to injury by an external agent.

报告了一例与矽肺相关的肺泡蛋白沉积症病例。一名58岁男性曾接触二氧化硅七年，症状出现三年后死亡。活检和尸检材料的光学显微镜检查显示有小的矽肺结节、二氧化硅颗粒和肺泡蛋白沉积症，并进行了超微结构研究以确定肺泡上皮和巨噬细胞的变化。该病例进一步说明了肺泡蛋白沉积症是肺部对外源性物质损伤的一种反应。