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一种用于O-连接的β-N-乙酰葡糖胺的合成凝集素。

A synthetic lectin for O-linked beta-N-acetylglucosamine.

作者信息

Ferrand Yann, Klein Emmanuel, Barwell Nicholas P, Crump Matthew P, Jiménez-Barbero Jesus, Vicent Cristina, Boons Geert-Jan, Ingale Sampat, Davis Anthony P

机构信息

School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.

出版信息

Angew Chem Int Ed Engl. 2009;48(10):1775-9. doi: 10.1002/anie.200804905.

DOI:10.1002/anie.200804905
PMID:19072969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2835298/
Abstract

Changing employment: Receptor 1 binds beta-N-acetylglucosaminyl (beta-GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, 1 is more selective than WGA. It favors especially the glycoside unit in glycopeptide 2, a model of the serine-O-GlcNAc posttranslational protein modification.

摘要

改变的结合活性

受体1与β-N-乙酰葡糖胺（β-GlcNAc）的结合强度比其与葡萄糖的结合强度高多达100倍。这种合成凝集素表现出与麦胚凝集素（WGA，一种用于结合GlcNAc的天然凝集素）相似的亲和力。值得注意的是，1比WGA更具选择性。它特别倾向于糖肽2中的糖苷单元，糖肽2是丝氨酸-O-GlcNAc翻译后蛋白质修饰的模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/de2b45c790ad/nihms181865f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/dfbfeb07bdd3/nihms181865f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/65876bbd6175/nihms181865f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/7f13325e7c24/nihms181865f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/de2b45c790ad/nihms181865f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/dfbfeb07bdd3/nihms181865f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/65876bbd6175/nihms181865f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/7f13325e7c24/nihms181865f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8298/2835298/de2b45c790ad/nihms181865f4.jpg

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