Fleming Mark D
Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Hematology Am Soc Hematol Educ Program. 2008:151-8. doi: 10.1182/asheducation-2008.1.151.
Systemic iron homeostasis depends on the regulated expression of hepcidin, a peptide hormone that negatively regulates iron egress from intestinal cells and macrophages by altering the expression of the cellular iron exporter ferroportin. In doing so, hepcidin can control both the total body iron by modulating intestinal iron absorption as well as promote iron available for erythropoiesis by affecting the efficiency with which macrophages recycle iron from effete red blood cells. This review focuses on the systemic and cellular physiology of hepcidin regulation in relation to iron stores, erythropoiesis, inflammation, and hypoxia and how hepcidin regulation and dysregulation contributes to normal iron homeostasis and iron metabolism disorders.
全身铁稳态依赖于铁调素的调控表达，铁调素是一种肽类激素，通过改变细胞铁输出蛋白铁转运蛋白的表达，对肠道细胞和巨噬细胞的铁流出起负调节作用。通过这种方式，铁调素既能通过调节肠道铁吸收来控制全身铁含量，又能通过影响巨噬细胞从衰老红细胞中回收铁的效率，促进可用于红细胞生成的铁供应。本综述重点关注铁调素调节在铁储存、红细胞生成、炎症和缺氧方面的全身和细胞生理学，以及铁调素调节和失调如何影响正常铁稳态和铁代谢紊乱。
