Knoth R L, Mair R G
University of New Hampshire, Durham 03824.
Behav Neurosci. 1991 Jun;105(3):375-85.
Rats were trained for 1,345 spatial nonmatching-to-sample (NMTS) trials, matched, assigned to pyrithiamine-induced thiamine deficiency (PTD) or control treatments, recovered, and re-tested for 400 trials of NMTS. The PTD model produced two bilaterally symmetrical lesions: one of medial thalamus that was centered on the internal medullary lamina (IML) and another involving the mammillary bodies. PTD rats with complete IML lesions showed a sharp drop in performance that persisted throughout posttreatment training. PTD rats with IML sparing were impaired immediately after treatment but improved to a level comparable to that of controls. For all animals, NMTS accuracy decreased for longer latency responses. PTD animals differed from controls primarily in the low frequency and inaccuracy of their short-latency (0-2.9 s) responses. The improvement of the PTD rats with IML sparing was marked by an increase in both the number and accuracy of short-latency responses.
大鼠接受了1345次空间样本不匹配（NMTS）试验的训练，进行匹配后，分为吡硫胺诱导的硫胺素缺乏（PTD）组或对照组进行处理，恢复后，再进行400次NMTS试验的重新测试。PTD模型产生了两个双侧对称的损伤：一个位于丘脑内侧，以内髓板（IML）为中心，另一个累及乳头体。IML完全损伤的PTD大鼠表现出性能急剧下降，在治疗后的整个训练过程中持续存在。IML未受损伤的PTD大鼠在治疗后立即受损，但随后改善到与对照组相当的水平。对于所有动物，NMTS准确性随着反应潜伏期延长而降低。PTD动物与对照组的主要区别在于其短潜伏期（0 - 2.9秒）反应的频率低且不准确。IML未受损伤的PTD大鼠的改善表现为短潜伏期反应的数量和准确性均增加。
