Mumby D G, Mana M J, Pinel J P, David E, Banks K
Department of Psychology, University of British Columbia, Canada.
Behav Neurosci. 1995 Dec;109(6):1209-14.
Pyrithiamine-induced thiamine deficiency (PTD) in rats is used to model the etiology, diencephalic neuropathology, and memory deficits of Korsakoff's amnesia. We assessed the performance of rats exposed to PTD on a test of object recognition--nonrecurring-items delayed nonmatching-to-sample (DNMS). PTD produced thalamic lesions similar to those of Korsakoff's amnesics and similar to those previously observed in PTD rats. PTD rats required more trials to master DNMS at a 4-s retention delay than did controls, and after they had done so, they performed more poorly than controls at delays of 15, 30, 60, and 120 s. DNMS deficits were also observed in PTD rats that received training prior to PTD treatment. These findings support the validity of the PTD rat model of Korsakoff's disease by demonstrating that PTD rats display object-recognition deficits that are similar to those reported in Korsakoff amnesics.
大鼠中的硫胺素拮抗剂诱导的硫胺素缺乏症（PTD）被用于模拟柯萨科夫失忆症的病因、间脑神经病理学和记忆缺陷。我们在一项物体识别测试——非重复项延迟样本匹配（DNMS）中评估了暴露于PTD的大鼠的表现。PTD产生的丘脑病变与柯萨科夫失忆症患者的病变相似，也与先前在PTD大鼠中观察到的病变相似。与对照组相比，PTD大鼠在4秒的保留延迟下掌握DNMS需要更多的试验次数，并且在掌握之后，它们在15秒、30秒、60秒和120秒的延迟下表现比对照组更差。在PTD治疗前接受训练的PTD大鼠中也观察到了DNMS缺陷。这些发现通过证明PTD大鼠表现出与柯萨科夫失忆症患者报告的相似的物体识别缺陷，支持了PTD大鼠模型对柯萨科夫病的有效性。
