Mair R G, Lacourse D M
Psychology Department, University of New Hampshire, Durham 03824.
Behav Neurosci. 1992 Aug;106(4):634-45. doi: 10.1037//0735-7044.106.4.634.
Rats were trained and matched on a delayed-nonmatching-to-sample (DNMTS) task and randomly assigned to treatment. In Experiment 1, radio-frequency (RF) lesions were aimed at lateral portions of the internal medullary lamina (L-IML), midline thalamus (MT), mammillary bodies (MB), and the combination of MT and MB. In Experiment 2, RF lesions were aimed at the fornix. After recovery, DNMTS was retrained at retention intervals retention interval of 3.0-18.0 s, the critical retention interval for 75% DNMTS accuracy was determined by a staircase procedure, and spontaneous exploration was observed in an open field. L-IML lesions produced significant deficits on DNMTS and exploratory behavior that were comparable to deficits on the same tasks in rats recovered from pyrithiamine-induced thiamine deficiency. Fornix lesions produced significant DNMTS deficits that were substantially smaller than for the L-IML group. The MT, MB, and MT+MB treatments had no significant effect on DNMTS.
大鼠在延迟非匹配样本（DNMTS）任务上接受训练并进行匹配，然后随机分配接受治疗。在实验1中，射频（RF）损伤针对内髓板外侧部分（L-IML）、中线丘脑（MT）、乳头体（MB）以及MT和MB的组合。在实验2中，RF损伤针对穹窿。恢复后，在3.0 - 18.0秒的保留间隔重新训练DNMTS，通过阶梯程序确定75% DNMTS准确性的关键保留间隔，并在旷场中观察自发探索行为。L-IML损伤在DNMTS和探索行为上产生了显著缺陷，这些缺陷与从硫胺素缺乏诱导的硫胺素缺乏症中恢复的大鼠在相同任务上的缺陷相当。穹窿损伤产生了显著的DNMTS缺陷，但比L-IML组的缺陷小得多。MT、MB和MT + MB治疗对DNMTS没有显著影响。
