Robinson J K, Mair R G
University of New Hampshire, Durham 03824.
Behav Neurosci. 1992 Aug;106(4):623-33.
Rats were trained on a spatial delayed-nonmatching-to-sample (DNMTS) task and assigned by block randomization to one of four treatments: pyrithiamine-induced thiamine deficiency (PTD), PTD with administration of MK-801 after 12 days, control with MK-801 treatment, and control without MK-801. After 15 days of treatment followed by 21 days of recovery, the PTD rats showed significant deficits for DNMTS accuracy at retention intervals (RI) that ranged from 3.0 s to 15.0 s, the RIs that produced 75% accuracy on DNMTS in staircase training, and the rate at which a novel radial arm maze task was learned. The PTD-treated rats had consistent lesions in the thalamus and the mammillary bodies. MK-801 protected rats from both behavioral deficits and brain lesions (assessed quantitatively and qualitatively) that were produced by the PTD treatment.
大鼠接受空间延迟非匹配样本（DNMTS）任务训练，并通过区组随机化分配到四种处理之一：硫胺素缺乏诱导的硫胺素缺乏（PTD）、12天后给予MK-801的PTD、MK-801处理的对照组和未给予MK-801的对照组。在15天的治疗后接着21天的恢复，PTD大鼠在3.0秒至15.0秒的保持间隔（RI）（阶梯训练中产生75%DNMTS准确率的RI）以及新的放射状臂迷宫任务的学习速率方面，表现出显著的DNMTS准确性缺陷。接受PTD处理的大鼠在丘脑和乳头体有一致性损伤。MK-801保护大鼠免受PTD处理所产生的行为缺陷和脑损伤（进行定量和定性评估）。
