Lourenço Sílvia V, Lobo Alice Z C, Boggio Paula, Fezzi Fernando, Sebastião Alexandre, Nico Marcello Menta S
Department of GeneralPathology, Dental School, University of São Paulo, São Paulo, Brazil.
Arch Dermatol. 2008 Dec;144(12):1627-30. doi: 10.1001/archderm.144.12.1627.
Orofacial granulomatosis is a clinical entity presenting with swelling of the facial and/or oral tissues in association with histologic evidence of noncaseating granulomatous inflammation. Labial swelling is the most common finding. Compromise of the gingival and periodontal tissues may occur but has rarely been described in the literature. Our objective was to characterize granulomatous gingivitis in patients with orofacial granulomatosis.
The study included 29 cases of orofacial granulomatosis seen in our clinic between January 1, 1989, and December 31, 2006. Of these 29, 5 had clinical evidence of gingival tumefaction and underwent gingival biopsy. Histologic examination of all the gingival biopsy specimens showed noncaseating granulomas, edema of the superficial lamina propria, and a chronic inflammatory infiltrate consisting predominantly of lymphocytes and multinucleated giant cells. Treatment options included anti-inflammatory therapy associated with periodontal care. Conclusion Gingival tumefaction with histologic evidence of granulomatous inflammation may occur in orofacial granulomatosis and might be more common than reported in the literature.
口面部肉芽肿病是一种临床病症，表现为面部和/或口腔组织肿胀，并伴有非干酪样肉芽肿性炎症的组织学证据。唇部肿胀是最常见的表现。牙龈和牙周组织可能受累，但在文献中很少有描述。我们的目的是对口面部肉芽肿病患者的肉芽肿性牙龈炎进行特征描述。
该研究纳入了1989年1月1日至2006年12月31日期间在我们诊所就诊的29例口面部肉芽肿病患者。在这29例患者中，5例有牙龈肿胀的临床证据并接受了牙龈活检。所有牙龈活检标本的组织学检查均显示非干酪样肉芽肿、固有层浅层水肿以及以淋巴细胞和多核巨细胞为主的慢性炎症浸润。治疗方案包括抗炎治疗及牙周护理。结论口面部肉芽肿病可能会出现伴有肉芽肿性炎症组织学证据的牙龈肿胀，且可能比文献报道的更为常见。
