Al Johani K, Moles D R, Hodgson T, Porter S R, Fedele S
Oral Medicine, UCL Eastman Dental Institute, London, UK.
Oral Dis. 2009 Apr;15(3):214-9. doi: 10.1111/j.1601-0825.2009.01512.x. Epub 2008 Feb 16.
There remain few studies describing in detail the early occurrence and long-term progression of clinical manifestations of orofacial granulomatosis (OFG) in a substantial number of patients.
The aim of this study was to determine the early and late clinical manifestations of a large case series of patients with OFG.
PATIENTS/METHODS: Clinically relevant data of 49 patients with OFG who attended an Oral Medicine unit in the UK were examined retrospectively. The analyzed parameters included occurrence and typology of initial manifestations at onset and with respect to long-term follow-up.
Five major patterns of disease onset were observed. Recurrent facial swelling with/without intra-oral manifestations was the single most common presentation at onset followed by intra-oral ulcers, and other intra-oral and neurological manifestations. The majority of patients later developed a spectrum of additional features.
OFG results in multiple manifestations at different time points. The disease onset is characterized by manifestations other than facial swelling in about half of affected individuals. However, patients can develop cosmetically unacceptable lip/facial swelling at a later stage. Nearly all affected individuals ultimately develop lip/facial swelling while about half of all patients develop oral ulceration.
目前很少有研究详细描述大量口面部肉芽肿病（OFG）患者临床表现的早期发生情况和长期进展。
本研究的目的是确定一大组OFG患者的早期和晚期临床表现。
患者/方法：对在英国一家口腔医学科室就诊的49例OFG患者的临床相关数据进行回顾性研究。分析的参数包括发病时及长期随访时初始表现的发生情况和类型。
观察到五种主要的疾病发病模式。伴有/不伴有口腔内表现的复发性面部肿胀是发病时最常见的单一表现，其次是口腔内溃疡以及其他口腔内和神经学表现。大多数患者后来出现了一系列其他特征。
OFG在不同时间点会导致多种表现。约一半的受累个体疾病发病的特征是面部肿胀以外的表现。然而，患者在后期可能会出现美容上难以接受的唇部/面部肿胀。几乎所有受累个体最终都会出现唇部/面部肿胀，而所有患者中约一半会出现口腔溃疡。
