Billiet Ludivine, Rouis Mustapha
UMR 7079 / Université Pierre et Marie Curie-Paris 6, Physiologie et Physiopathologie, Bât. A. 5eme étage/Case courrier 256, 7, Quai St-Bernard, 75252 Paris Cedex 5, France.
Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):293-6. doi: 10.2174/187152908786786179.
The regulation of cellular reduction/oxidation (redox) balance is critically determined by several antioxidant systems such as the thioredoxin-1 (Trx-1) which reduces disulfides on targeted proteins. In addition, intracellular Trx-1 exerts most of its antioxidant properties through scavenging of reactive oxygen species. Moreover, it acts as a cofactor for several enzymes and plays an important role in the regulation of redox-sensitive transcription factors. Several studies have reported that Trx-1 activity can be modulated by the interaction with vitamin D3-upregulated protein (VDUP-1) (also called Txnip for thioredoxin interacting protein-1 or TBP-2 for Trx-binding protein-2). Trx-1 secretion has been reported to occur in conditions associated with oxidative stress and inflammation. Beneficial effects of elevated plasma Trx-1 levels on various pathologies were reported in mice. In conclusion, oxidative stress is an important actor in various pathologies including cardio- and cerebro-vascular diseases. Therefore, controlling the redox status by increasing the activity of Trx-1 seems to be a novel and an attractive approach.
细胞氧化还原平衡的调节主要由几种抗氧化系统决定，比如硫氧还蛋白-1（Trx-1），它能还原目标蛋白上的二硫键。此外，细胞内的Trx-1通过清除活性氧发挥其大部分抗氧化特性。而且，它作为几种酶的辅助因子，在氧化还原敏感转录因子的调节中起重要作用。多项研究报道，Trx-1的活性可通过与维生素D3上调蛋白（VDUP-1）（也称为硫氧还蛋白相互作用蛋白-1的Txnip或Trx结合蛋白-2的TBP-2）相互作用来调节。据报道，Trx-1在与氧化应激和炎症相关的情况下会分泌。在小鼠中，血浆Trx-1水平升高对各种病理状况有有益作用。总之，氧化应激是包括心脑血管疾病在内的各种病理状况中的一个重要因素。因此，通过提高Trx-1的活性来控制氧化还原状态似乎是一种新颖且有吸引力的方法。
