Tanianskiĭ D A, Firova E M, Shatilina L V, Denisenko A D
Kardiologiia. 2008;48(12):20-5.
Aim of the study was to elucidate possible role of adiponectin in development of clinico-metabolic derangements in metabolic syndrome (MS). We examined 35 men and 45 women (mean age 58.0+/-8.8 years). Adiponectin level was significantly lower (p<0.01) in patients with MS (5.8+/-4.6) compared with subjects without MS (9.2+/-5.3 mkg/ml). Body mass index (BMI), waist circumference (WC), index of insulin resistance , levels of glucose, insulin, free fatty acids (FFA), triglycerides (TG) were lower in 3rd tertile of distribution of adiponectin blood content compared with 1st tertile. Significant negative correlations were found between adiponectin content and BMI (r=-0.36), WC (r=-0.34), index (r=-0.31), level of diastolic arterial pressure (r=-0.34), concentrations of glucose (r=-0.24), insulin (r=-0.26), FFA (r=-0.24), TG (r=-0.45), uric acid (r=-0.29). Correlation between adiponectin and level of high density lipoprotein cholesterol was positive (I=0.26). However after adjustment for MI, sex, and age adiponectin content correlated significantly only with concentration of TG (r=-0.27) and diastolic arterial pressure (r=-0.26). Regression analysis revealed independent from factors presented above role of adiponectin in determination of blood level of TG (beta=-0.30, p=0.02).
本研究的目的是阐明脂联素在代谢综合征（MS）临床代谢紊乱发展中的可能作用。我们检查了35名男性和45名女性（平均年龄58.0±8.8岁）。与无MS的受试者（9.2±5.3μg/ml）相比，MS患者的脂联素水平显著降低（p<0.01）（5.8±4.6）。与脂联素血含量分布的第一三分位数相比，在第三三分位数中，体重指数（BMI）、腰围（WC）、胰岛素抵抗指数、血糖、胰岛素、游离脂肪酸（FFA）、甘油三酯（TG）水平较低。脂联素含量与BMI（r=-0.36）、WC（r=-0.34）、指数（r=-0.31）、舒张压水平（r=-0.34）、血糖浓度（r=-0.24）、胰岛素（r=-0.26）、FFA（r=-0.24）、TG（r=-0.45）、尿酸（r=-0.29）之间存在显著负相关。脂联素与高密度脂蛋白胆固醇水平之间的相关性为正（r=0.26）。然而，在对心肌梗死、性别和年龄进行校正后，脂联素含量仅与TG浓度（r=-0.27）和舒张压（r=-0.26）显著相关。回归分析显示，脂联素在决定TG血水平方面独立于上述因素起作用（β=-0.30，p=0.02）。
