Karagiannides Iordanes, Pothoulakis Charalabos
Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7019, USA.
Ann N Y Acad Sci. 2008 Nov;1144:127-35. doi: 10.1196/annals.1418.009.
The ability of fat tissue cells to produce proinflammatory cytokines and the concept that obesity represents a low-grade inflammatory response have been well documented during the past decade. The effects of fat-mediated inflammation on metabolic pathologies have also been drawing increasing interest. However, very little is known on the potential effects of adipose tissue in the pathophysiology of gastrointestinal diseases with an inflammatory component, such as inflammatory bowel disease (IBD). The development of large fat masses around the inflamed intestine during Crohn's disease makes this tissue a candidate for more intense investigation in studies aiming to gain insights into the pathogenesis and progress of the disease. Furthermore, neuropeptides act in many cases in a proinflammatory manner and are shown to participate in the pathogenesis of intestinal inflammation in animal models of IBD. However, the potential of these molecules to interact with fat cells in the context of IBD has not been investigated. In this review the authors' most recent data related to the effects of neuropeptides on noninflammatory fat tissue components are described. In addition, a discussion to associate neuropeptide-induced, adipose tissue-mediated responses with the generation of intestinal inflammatory conditions such as Crohn's disease is included.
在过去十年中，脂肪组织细胞产生促炎细胞因子的能力以及肥胖代表一种低度炎症反应的概念已得到充分证明。脂肪介导的炎症对代谢性疾病的影响也越来越受到关注。然而，关于脂肪组织在具有炎症成分的胃肠道疾病（如炎症性肠病，IBD）病理生理学中的潜在作用却知之甚少。在克罗恩病期间，发炎肠道周围会形成大量脂肪团，这使得该组织成为旨在深入了解疾病发病机制和进展的研究中更值得深入研究的对象。此外，神经肽在许多情况下以促炎方式起作用，并已证明在IBD动物模型中参与肠道炎症的发病机制。然而，在IBD背景下这些分子与脂肪细胞相互作用的潜力尚未得到研究。在这篇综述中，描述了作者关于神经肽对非炎症性脂肪组织成分影响的最新数据。此外，还讨论了将神经肽诱导的、脂肪组织介导的反应与诸如克罗恩病等肠道炎症状态的产生联系起来。
