Buitrago William, Joseph Aaron K
Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA.
Dermatol Ther. 2008 Nov-Dec;21(6):459-66. doi: 10.1111/j.1529-8019.2008.00247.x.
Sebaceous carcinoma (SC) is a rare tumor with a high rate of local recurrence and metastasis to lymph nodes and organs. The majority of SCs occur in the periocular region frequently presenting as painless, round subcutaneous nodules with a high tendency of diffuse and invasive growth in the eyelid and conjunctiva. It frequently masquerades as inflammatory conditions or as other tumors leading to delay in diagnosis, inappropriate treatment and increased morbidity and mortality. Sebaceous carcinoma is associated with Muir-Torre syndrome, a genetic condition presenting with sebaceous skin tumors associated with internal malignancy. Therefore, SC patients must be carefully evaluated and referred to an internist or gastroenterologist when indicated. Surgery is the definitive therapy for SC. In recent years, less radical surgical strategies are being used with improved outcomes. Current studies demonstrate that Mohs micrographic surgery (MMS) provides maximal tissue conservation and lower recurrence rates. Greater awareness and understanding of SC and its behavior has led to earlier diagnosis and appropriate treatment.
皮脂腺癌（SC）是一种罕见肿瘤，局部复发率高，易转移至淋巴结和器官。大多数皮脂腺癌发生于眼周区域，常表现为无痛性圆形皮下结节，在眼睑和结膜处有高度弥漫性和浸润性生长倾向。它常伪装成炎症性疾病或其他肿瘤，导致诊断延迟、治疗不当，以及发病率和死亡率增加。皮脂腺癌与穆尔-托雷综合征相关，这是一种遗传性疾病，表现为伴有内脏恶性肿瘤的皮脂腺皮肤肿瘤。因此，必须对皮脂腺癌患者进行仔细评估，并在必要时转诊至内科医生或胃肠病学家处。手术是皮脂腺癌的确定性治疗方法。近年来，采用了不太激进的手术策略，效果有所改善。目前的研究表明，莫氏显微外科手术（MMS）能最大程度地保留组织并降低复发率。对皮脂腺癌及其行为的更多认识和了解已导致更早的诊断和适当的治疗。
