Kolarik B, Lagercrantz L, Sundell J
International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark, Lyngby, Denmark.
Indoor Air. 2009 Apr;19(2):145-52. doi: 10.1111/j.1600-0668.2008.00572.x. Epub 2008 Dec 11.
The concentration of nitric oxide (NO) in exhaled and aspirated nasal air was used to objectively assess human response to indoor air pollutants in a climate chamber exposure experiment. The concentration of NO was measured before exposure, after 2, and 4.5 h of exposure, using a chemiluminescence NO analyzer. Sixteen healthy female subjects were exposed to two indoor air pollutants and to a clean reference condition for 4.5 h. Subjective assessments of the environment were obtained by questionnaires. After exposure (4.5 h) to the two polluted conditions a small increase in NO concentration in exhaled air was observed. After exposure to the reference condition the mean NO concentration was significantly reduced compared to pre-exposure. Together these changes resulted in significant differences in exhaled NO between exposure to reference and polluted conditions. NO in nasal air was not affected by the exposures. The results may indicate an association between polluted indoor air and subclinical inflammation.
Measurement of nitric oxide in exhaled air is a possible objective marker of subclinical inflammation in healthy adults.
在气候舱暴露实验中，利用呼出气体和鼻腔吸入气体中一氧化氮（NO）的浓度来客观评估人体对室内空气污染物的反应。使用化学发光NO分析仪在暴露前、暴露2小时和4.5小时后测量NO浓度。16名健康女性受试者在气候舱中暴露于两种室内空气污染物以及清洁的对照环境中4.5小时。通过问卷调查获得对环境的主观评估。在暴露于两种污染环境（4.5小时）后，观察到呼出气体中NO浓度略有增加。暴露于对照环境后，与暴露前相比，平均NO浓度显著降低。这些变化共同导致在暴露于对照环境和污染环境之间呼出NO存在显著差异。鼻腔气体中的NO不受这些暴露的影响。结果可能表明污染的室内空气与亚临床炎症之间存在关联。
测量呼出气体中的一氧化氮可能是健康成年人亚临床炎症的一种客观标志物。
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