Atmaca Ali Fuat, Serefoğlu Ege Can, Eroğlu Muzaffer, Gürdal Mesut, Metin Ahmet, Kayigil Onder
Urology Clinic, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
Urol Int. 2008;81(4):456-61. doi: 10.1159/000167847. Epub 2008 Dec 10.
To examine the time-dependent biomechanical properties of four different implanted synthetic materials.
18 New Zealand rabbits were randomly categorized into three groups: group 1 to be evaluated at the 2nd week, group 2 at the 8th week, and group 3 at the 12th week. Before the implantation, baseline values were obtained. Each of the 2 x 5 cm sized materials of mersilene, prolene, ultrapro and vypro mesh were placed in the anterior abdominal fascia. The mesh materials were removed, tensile strength (N/mm(2)) and ultimate strain (%) were measured by tensinometry and surface area losses (cm(2)) were calculated.
Tensile strength values (mean +/- SD) were 9.2 +/- 1.5, 8.5 +/- 1.2 for mersilene, 25.2 +/- 7.3, 14.0 +/- 2.9 for prolene, 2.2 +/- 0.6, 12.5 +/- 1.4 for ultrapro and 8.1 +/- 1.6, 7.0 +/- 1.8 for vypro at baseline and the 12th week. Ultimate strain values (mean +/- SD) were 131.2 +/- 46.1, 110.4 +/- 98.6 for mersilene, 181.0 +/- 26.4, 78.5 +/- 14.4 for prolene, 91.5 +/- 8.2, 89.6 +/- 20.5 for ultrapro and 84.3 +/- 8.9, 55.0 +/- 13.2 for vypro at baseline and the 12th week. Surface areas (mean +/- SD) were 8.87 +/- 0.14, 9.38 +/- 0.17, 8.4 +/- 0.32 and 8.76 +/- 0.16 for mersilene, prolene, ultrapro and vypro at the 12th week respectively.
Although prolene mesh demonstrated a decrease in its tensile strength it still remains the highest at the 12th week. Considering the significant time-dependent increase in its tensile strength, ultrapro mesh should be studied in humans. A final decision on the preference of ultrapro mesh in sling surgery could be reached after such studies.
研究四种不同植入合成材料的时间依赖性生物力学特性。
18只新西兰兔随机分为三组：第1组在第2周进行评估，第2组在第8周，第3组在第12周。植入前获取基线值。将尺寸为2×5 cm的美西奈、普理灵、超普和维普补片材料分别置于腹前筋膜。取出补片材料，通过张力测定法测量拉伸强度（N/mm²）和极限应变（%），并计算表面积损失（cm²）。
美西奈在基线和第12周时的拉伸强度值（均值±标准差）分别为9.2±1.5、8.5±1.2；普理灵为25.2±7.3、14.0±2.9；超普为2.2±0.6、12.5±1.4；维普为8.1±1.6、7.0±1.8。美西奈、普理灵、超普和维普在基线和第12周时的极限应变值（均值±标准差）分别为131.2±46.1、110.4±98.6；181.0±26.4、78.5±14.4；91.5±8.2、89.6±20.5；84.3±8.9、55.0±13.2。第12周时，美西奈、普理灵、超普和维普的表面积（均值±标准差）分别为8.87±0.14、9.38±0.17、8.4±0.32和8.76±0.16。
尽管普理灵补片的拉伸强度有所下降，但在第12周时仍为最高。鉴于超普补片的拉伸强度随时间显著增加，应在人体中进行研究。经过此类研究后，才能最终决定超普补片在吊带手术中的首选地位。
