Yang Xiu-Jiang, Lin Yong, Zeng Xin, Shi Jian, Chen Yue-Xiang, Shen Jian-Wei, Xie Wei-Fen
Department of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Pancreatology. 2009;9(1-2):111-5. doi: 10.1159/000178881. Epub 2008 Dec 12.
Endoscopic clearance of large or impacted stones in the main pancreatic duct (MPD) remains a clinical challenge. In this study, we attempted to technically modify the metallic stent to facilitate the clearance of large pancreatic stones in 4 patients, hoping to lower the operative risks and shorten hospital stay.
Four patients with chronic pancreatitis and large stones in the MPD received endoscopic treatment. Inclusion criteria were: (1) pancreatic intraductal stones (number >3; diameter >or=10 mm) and strictures identified in the distal MPD; (2) calculi mainly located in the head, neck and/or body of the pancreas, and (3) failed clearance of stones using a balloon catheter or Dormia basket. Before clearing the pancreatic calculi completely, a technically modified uncovered self-expandable metallic pancreatic stent was implanted in the MPD for 4-7 days to dilate the ductal stenosis, and then drawn out through the working channel.
As the MPD had been sufficiently expanded by the stent, the calculi were removed completely and uneventfully by the balloon or Dormia basket in all 4 patients, without inducing major postoperative complications. A 9- to 15-month follow-up did not find major complications or recurrence of large calculi in the MPD.
Technically modified metallic stenting is a minimally invasive and clinically feasible alternative to extracorporeal shock wave lithotripsy in the management of large pancreatic duct stones.
内镜下清除主胰管(MPD)内的大结石或嵌顿结石仍然是一项临床挑战。在本研究中,我们尝试对金属支架进行技术改良,以促进4例患者大胰石的清除,希望降低手术风险并缩短住院时间。
4例慢性胰腺炎且MPD内有大结石的患者接受了内镜治疗。纳入标准为:(1)胰管内结石(数量>3;直径≥10 mm)且在MPD远端发现狭窄;(2)结石主要位于胰腺头部、颈部和/或体部;(3)使用球囊导管或多尔米亚网篮清除结石失败。在完全清除胰结石之前,将经技术改良的未覆盖自膨式金属胰管支架植入MPD 4 - 7天以扩张导管狭窄,然后通过工作通道取出。
由于支架已充分扩张MPD,所有4例患者的结石均通过球囊或多尔米亚网篮完全且顺利地清除,未引发重大术后并发症。9至15个月的随访未发现MPD有重大并发症或大结石复发。
在处理大胰管结石方面,经技术改良的金属支架置入术是体外冲击波碎石术的一种微创且临床可行的替代方法。